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thp 1 aml atcc  (ATCC)


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    Structured Review

    ATCC thp 1 aml atcc
    Thp 1 Aml Atcc, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 20286 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/thp+1+aml+atcc/THP-1/us11633500-1456-225-227
    Average 99 stars, based on 20286 article reviews
    thp 1 aml atcc - by Bioz Stars, 2026-10
    99/100 stars

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    Sequencing:

    Article Title: Antibody drug conjugates (ADC) that bind to FLT3 proteins
    Article Snippet: .. Secondary Cell Line Cancer Type Source Unstained Detection Isotype cHv62-1b21.1 MFR Karpas-299 ALCL DSMZ 623 596 569 634 1 REH ALL ATCC 220 236 235 16200 69 EOL-1 AML Sigma/HPA 282 292 281 14000 50 MOLM-13 AML DSMZ 303 313 320 14000 44 MONOMAC-1 AML Creative Bioarray 315 348 338 11400 34 MV-4-11 AML ATCC 344 355 366 2875 8 OCI-AML2 AML DSMZ 343 337 329 5646 17 PL-21 AML DSMZ 598 584 570 3715 7 SKM-1 AML DSMZ 465 449 445 3208 7 THP-1 AML ATCC 486 475 474 19700 42 RS4; 11 B-ALL ATCC 184 213 213 18400 86 SEM B-ALL DSMZ 181 207 212 132000 623 NALM-1 CML ATCC 197 254 262 12900 49 TABLE VII Antibody Sequence of v62-1b37.1. ..

    Article Title: Antibody drug conjugates (ADC) that bind to FLT3 proteins
    Article Snippet: .. Cell Line Cancer Type Source Unstained Secondary Detection Isotype cHv62-1b21.1 MFR Karpas-299 ALCL DSMZ 623 596 569 634 1 REH ALL ATCC 220 236 235 16200 69 EOL-1 AML Sigma/HPA 282 292 281 14000 50 MOLM-13 AML DSMZ 303 313 320 14000 44 MONOMAC-1 AML Creative Bioarray 315 348 338 11400 34 MV-4-11 AML ATCC 344 355 366 2875 8 OCI-AML2 AML DSMZ 343 337 329 5646 17 PL-21 AML DSMZ 598 584 570 3715 7 SKM-1 AML DSMZ 465 449 445 3208 7 THP-1 AML ATCC 486 475 474 19700 42 RS4; 11 B-ALL ATCC 184 213 213 18400 86 SEM B-ALL DSMZ 181 207 212 132000 623 NALM-1 CML ATCC 197 254 262 12900 49 TABLE VII Antibody Sequence of v62-1b37.1. ..

    FACS:

    Article Title: Antibody drug conjugates (ADC) that bind to CD37 proteins
    Article Snippet: .. CDR Kabat Chothia Contact CDR-L1 L24-L34 L24-L34 L30-L36 CDR-L2 L50-L56 L50-L56 L46-L55 CDR-L3 L89-L97 L89-L97 L89-L96 CDR-H1* H31-H35 H26-H32 H30-H35 CDR-H1** H31-H35 H26-H32 H30-H35 CDR-H2 H50-H65 H52-H56 H47-H58 CDR-H3 H95-H102 H95-H102 H93-H101 *Kabat Numbering **Chothia Numbering TABLE VI Table of Geometric Mean values and Mean Florescence ratio (MFR) values in FACS assay. secondary HvCD37- Cell line Cancer type Source unstained detection Isotype 6b15.1.1 MFR JVM-3 CLL DSMZ 1871 1792 1931 236000 122 SU-DHL-4 DLBCL DSMZ 1097 1046 1053 697000 662 DOHH-2 Follicular DSMZ 888 1172 840 488000 581 MOLT-4 ALL NCI 1494 1280 1310 3606 3 Granta-519* MCL DSMZ 1363 1408 15400 524000 372 Ramos RR XCL Burkitt's ATCC in-vivo selection 679 1093 693 97276 140 (rituxan resistant) Mino MCL ATCC 1438 1409 1484 446000 301 Mino XCL MCL ATCC in-vivo xenograft 201 198 200 63100 316 Ramos Burkitt's ATCC 1232 1117 1151 615000 534 Raji Burkitt's ATCC 1590 1648 1761 237000 135 Daudi Burkitt's ATCC 1513 1780 2039 79000 39 WSU-DLCL-2 DLBCL DSMZ 1214 1149 1203 666000 554 REC-1 MCL DSMZ 870 6149 1013 345554 341 BDCM AML ATCC 219 286 290 18500 64 MOLM-13 AML DSMZ 263 245 240 1514 6 R54-11 ALL ATCC 154 149 155 4054 26 EoL-1 AML Sigma/HPA 197 189 189 604 3 Kasumi-1 AML DSMZ 172 190 188 1710 9 MV-4-11 AML ATCC 263 249 247 2065 8 THP-1 AML ATCC 266 296 324 7355 23 KG-1* AML NCI 985 1787 8190 18100 10 Hel 92.1* AML ATCC 1455 1521 4216 42600 28 HL-60 AML ATCC 867 889 967 4602 5 Note: *All MFR ratios calculated with the Isotype control as reference, except for Granta-519, KG-1 and Hel 92.1 where the secondary detection was used as reference due to the high Isotype control background binding. ..

    Article Title: Antibody drug conjugates (ADC) that bind to CD37 proteins
    Article Snippet: .. CDR Kabat Chothia Contact CDR-L1 L24-L34 L24-L34 L30-L36 CDR-L2 L50-L56 L50-L56 L46-L55 CDR-L3 L89-L97 L89-L97 L89-L96 CDR-H1* H31-H35 H26-H32 H30-H35 CDR-H1** H31-H35 H26-H32 H30-H35 CDR-H2 H50-H65 H52-H56 H47-H58 CDR-H3 H95-H102 H95-H102 H93-H101 *Kabat Numbering **Chothia Numbering TABLE VI Table of Geometric Mean values and Mean Florescence ratio (MFR) values in FACS assay. secondary HvCD37- Cell line Cancer type Source unstained detection Isotype 6b15.1.1 MFR JVM-3 CLL DSMZ 1871 1792 1931 236000 122 SU-DHL-4 DLBCL DSMZ 1097 1046 1053 697000 662 DOHH-2 Follicular DSMZ 888 1172 840 488000 581 MOLT-4 ALL NCl 1494 1280 1310 3606 3 Granta-519* MCL DSMZ 1363 1408 15400 524000 372 Ramos RR XCL Burkitt's ATCC in-vivo selection 679 1093 693 97276 140 (rituxan resistant) Mino MCL ATCC 1438 1409 1484 446000 301 Mino XCL MCL ATCC in-vivo xenograft 201 198 200 63100 316 Ramos Burkitt's ATCC 1232 1117 1151 615000 534 Raji Burkitt's ATCC 1590 1648 1761 237000 135 Daudi Burkitt's ATCC 1513 1780 2039 79000 39 WSU-DLCL-2 DLBCL DSMZ 1214 1149 1203 666000 554 REC-1 MCL DSMZ 870 6149 1013 345554 341 BDCM AML ATCC 219 286 290 18500 64 MOLM-13 AML DSMZ 263 245 240 1514 6 RS4-11 ALL ATCC 154 149 155 4054 26 EoL-1 AML Sigma/HPA 197 189 189 604 3 Kasumi-1 AML DSMZ 172 190 188 1710 9 MV-4-11 AML ATCC 263 249 247 2065 8 THP-1 AML ATCC 266 296 324 7355 23 KG-1* AML NCl 985 1787 8190 18100 10 Hel 92.1* AML ATCC 1455 1521 4216 42600 28 HL-60 AML ATCC 867 889 967 4602 5 Note: *All MFR ratios calculated with the Isotype control as reference, except for Granta-519, KG-1 and Hel 92.1 where the secondary detection was used as reference due to the high Isotype control background binding. ..

    Article Title: Antibody drug conjugates (ADC) that bind to CD37 proteins
    Article Snippet: .. CDR Kabat Chothia Contact CDR-L1 L24-L34 L24-L34 L30-L36 CDR-L2 L50-L56 L50-L56 L46-L55 CDR-L3 L89-L97 L89-L97 L89-L96 CDR-H1* H31-H35 H26-H32 H30-H35 CDR-H1** H31-H35 H26-H32 H30-H35 CDR-H2 H50-H65 H52-H56 H47-H58 CDR-H3 H95-H102 H95-H102 H93-H101 *Kabat Numbering **Chothia Numbering TABLE VI Table of Geometric Mean values and Mean Florescence ratio (MFR) values in FACS assay. secondary HvCD37- Cell line Cancer type Source unstained detection Isotype 6b15.1.1 MFR JVM-3 CLL DSMZ 1871 1792 1931 236000 122 SU-DHL-4 DLBCL DSMZ 1097 1046 1053 697000 662 DOHH-2 Follicular DSMZ 888 1172 840 488000 581 MOLT-4 ALL NCI 1494 1280 1310 3606 3 Granta-519* MCL DSMZ 1363 1408 15400 524000 372 Ramos RR XCL Burkitt's ATCC in-vivo selection (rituxan resistant) 679 1093 693 97276 140 Mino MCL ATCC 1438 1409 1484 446000 301 Mino XCL MCL ATCC in-vivo xenograft 201 198 200 63100 316 Ramos Burkitt's ATCC 1232 1117 1151 615000 534 Raji Burkitt's ATCC 1590 1648 1761 237000 135 Daudi Burkitt's ATCC 1513 1780 2039 79000 39 WSU-DLCL-2 DLBCL DSMZ 1214 1149 1203 666000 554 REC-1 MCL DSMZ 870 6149 1013 345554 341 BDCM AML ATCC 219 286 290 18500 64 MOLM-13 AML DSMZ 263 245 240 1514 6 RS4-11 ALL ATCC 154 149 155 4054 26 EoL-1 AML Sigma/HPA 197 189 189 604 3 Kasumi-1 AML DSMZ 172 190 188 1710 9 MV-4-11 AML ATCC 263 249 247 2065 8 THP-1 AML ATCC 266 296 324 7355 23 KG-1* AML NCI 985 1787 8190 18100 10 Hel 92.1* AML ATCC 1455 1521 4216 42600 28 HL-60 AML ATCC 867 889 967 4602 5 Note: *All MFR ratios calculated with the Isotype control as reference, except for Granta-519, KG-1 and Hel 92.1 where the secondary detection was used as reference due to the high Isotype control background binding. ..

    Selection:

    Article Title: Antibody drug conjugates (ADC) that bind to CD37 proteins
    Article Snippet: .. CDR Kabat Chothia Contact CDR-L1 L24-L34 L24-L34 L30-L36 CDR-L2 L50-L56 L50-L56 L46-L55 CDR-L3 L89-L97 L89-L97 L89-L96 CDR-H1* H31-H35 H26-H32 H30-H35 CDR-H1** H31-H35 H26-H32 H30-H35 CDR-H2 H50-H65 H52-H56 H47-H58 CDR-H3 H95-H102 H95-H102 H93-H101 *Kabat Numbering **Chothia Numbering TABLE VI Table of Geometric Mean values and Mean Florescence ratio (MFR) values in FACS assay. secondary HvCD37- Cell line Cancer type Source unstained detection Isotype 6b15.1.1 MFR JVM-3 CLL DSMZ 1871 1792 1931 236000 122 SU-DHL-4 DLBCL DSMZ 1097 1046 1053 697000 662 DOHH-2 Follicular DSMZ 888 1172 840 488000 581 MOLT-4 ALL NCI 1494 1280 1310 3606 3 Granta-519* MCL DSMZ 1363 1408 15400 524000 372 Ramos RR XCL Burkitt's ATCC in-vivo selection 679 1093 693 97276 140 (rituxan resistant) Mino MCL ATCC 1438 1409 1484 446000 301 Mino XCL MCL ATCC in-vivo xenograft 201 198 200 63100 316 Ramos Burkitt's ATCC 1232 1117 1151 615000 534 Raji Burkitt's ATCC 1590 1648 1761 237000 135 Daudi Burkitt's ATCC 1513 1780 2039 79000 39 WSU-DLCL-2 DLBCL DSMZ 1214 1149 1203 666000 554 REC-1 MCL DSMZ 870 6149 1013 345554 341 BDCM AML ATCC 219 286 290 18500 64 MOLM-13 AML DSMZ 263 245 240 1514 6 R54-11 ALL ATCC 154 149 155 4054 26 EoL-1 AML Sigma/HPA 197 189 189 604 3 Kasumi-1 AML DSMZ 172 190 188 1710 9 MV-4-11 AML ATCC 263 249 247 2065 8 THP-1 AML ATCC 266 296 324 7355 23 KG-1* AML NCI 985 1787 8190 18100 10 Hel 92.1* AML ATCC 1455 1521 4216 42600 28 HL-60 AML ATCC 867 889 967 4602 5 Note: *All MFR ratios calculated with the Isotype control as reference, except for Granta-519, KG-1 and Hel 92.1 where the secondary detection was used as reference due to the high Isotype control background binding. ..

    Article Title: Antibody drug conjugates (ADC) that bind to CD37 proteins
    Article Snippet: .. CDR Kabat Chothia Contact CDR-L1 L24-L34 L24-L34 L30-L36 CDR-L2 L50-L56 L50-L56 L46-L55 CDR-L3 L89-L97 L89-L97 L89-L96 CDR-H1* H31-H35 H26-H32 H30-H35 CDR-H1** H31-H35 H26-H32 H30-H35 CDR-H2 H50-H65 H52-H56 H47-H58 CDR-H3 H95-H102 H95-H102 H93-H101 *Kabat Numbering **Chothia Numbering TABLE VI Table of Geometric Mean values and Mean Florescence ratio (MFR) values in FACS assay. secondary HvCD37- Cell line Cancer type Source unstained detection Isotype 6b15.1.1 MFR JVM-3 CLL DSMZ 1871 1792 1931 236000 122 SU-DHL-4 DLBCL DSMZ 1097 1046 1053 697000 662 DOHH-2 Follicular DSMZ 888 1172 840 488000 581 MOLT-4 ALL NCl 1494 1280 1310 3606 3 Granta-519* MCL DSMZ 1363 1408 15400 524000 372 Ramos RR XCL Burkitt's ATCC in-vivo selection 679 1093 693 97276 140 (rituxan resistant) Mino MCL ATCC 1438 1409 1484 446000 301 Mino XCL MCL ATCC in-vivo xenograft 201 198 200 63100 316 Ramos Burkitt's ATCC 1232 1117 1151 615000 534 Raji Burkitt's ATCC 1590 1648 1761 237000 135 Daudi Burkitt's ATCC 1513 1780 2039 79000 39 WSU-DLCL-2 DLBCL DSMZ 1214 1149 1203 666000 554 REC-1 MCL DSMZ 870 6149 1013 345554 341 BDCM AML ATCC 219 286 290 18500 64 MOLM-13 AML DSMZ 263 245 240 1514 6 RS4-11 ALL ATCC 154 149 155 4054 26 EoL-1 AML Sigma/HPA 197 189 189 604 3 Kasumi-1 AML DSMZ 172 190 188 1710 9 MV-4-11 AML ATCC 263 249 247 2065 8 THP-1 AML ATCC 266 296 324 7355 23 KG-1* AML NCl 985 1787 8190 18100 10 Hel 92.1* AML ATCC 1455 1521 4216 42600 28 HL-60 AML ATCC 867 889 967 4602 5 Note: *All MFR ratios calculated with the Isotype control as reference, except for Granta-519, KG-1 and Hel 92.1 where the secondary detection was used as reference due to the high Isotype control background binding. ..

    Article Title: Antibody drug conjugates (ADC) that bind to CD37 proteins
    Article Snippet: .. CDR Kabat Chothia Contact CDR-L1 L24-L34 L24-L34 L30-L36 CDR-L2 L50-L56 L50-L56 L46-L55 CDR-L3 L89-L97 L89-L97 L89-L96 CDR-H1* H31-H35 H26-H32 H30-H35 CDR-H1** H31-H35 H26-H32 H30-H35 CDR-H2 H50-H65 H52-H56 H47-H58 CDR-H3 H95-H102 H95-H102 H93-H101 *Kabat Numbering **Chothia Numbering TABLE VI Table of Geometric Mean values and Mean Florescence ratio (MFR) values in FACS assay. secondary HvCD37- Cell line Cancer type Source unstained detection Isotype 6b15.1.1 MFR JVM-3 CLL DSMZ 1871 1792 1931 236000 122 SU-DHL-4 DLBCL DSMZ 1097 1046 1053 697000 662 DOHH-2 Follicular DSMZ 888 1172 840 488000 581 MOLT-4 ALL NCI 1494 1280 1310 3606 3 Granta-519* MCL DSMZ 1363 1408 15400 524000 372 Ramos RR XCL Burkitt's ATCC in-vivo selection (rituxan resistant) 679 1093 693 97276 140 Mino MCL ATCC 1438 1409 1484 446000 301 Mino XCL MCL ATCC in-vivo xenograft 201 198 200 63100 316 Ramos Burkitt's ATCC 1232 1117 1151 615000 534 Raji Burkitt's ATCC 1590 1648 1761 237000 135 Daudi Burkitt's ATCC 1513 1780 2039 79000 39 WSU-DLCL-2 DLBCL DSMZ 1214 1149 1203 666000 554 REC-1 MCL DSMZ 870 6149 1013 345554 341 BDCM AML ATCC 219 286 290 18500 64 MOLM-13 AML DSMZ 263 245 240 1514 6 RS4-11 ALL ATCC 154 149 155 4054 26 EoL-1 AML Sigma/HPA 197 189 189 604 3 Kasumi-1 AML DSMZ 172 190 188 1710 9 MV-4-11 AML ATCC 263 249 247 2065 8 THP-1 AML ATCC 266 296 324 7355 23 KG-1* AML NCI 985 1787 8190 18100 10 Hel 92.1* AML ATCC 1455 1521 4216 42600 28 HL-60 AML ATCC 867 889 967 4602 5 Note: *All MFR ratios calculated with the Isotype control as reference, except for Granta-519, KG-1 and Hel 92.1 where the secondary detection was used as reference due to the high Isotype control background binding. ..

    Control:

    Article Title: Antibody drug conjugates (ADC) that bind to CD37 proteins
    Article Snippet: .. CDR Kabat Chothia Contact CDR-L1 L24-L34 L24-L34 L30-L36 CDR-L2 L50-L56 L50-L56 L46-L55 CDR-L3 L89-L97 L89-L97 L89-L96 CDR-H1* H31-H35 H26-H32 H30-H35 CDR-H1** H31-H35 H26-H32 H30-H35 CDR-H2 H50-H65 H52-H56 H47-H58 CDR-H3 H95-H102 H95-H102 H93-H101 *Kabat Numbering **Chothia Numbering TABLE VI Table of Geometric Mean values and Mean Florescence ratio (MFR) values in FACS assay. secondary HvCD37- Cell line Cancer type Source unstained detection Isotype 6b15.1.1 MFR JVM-3 CLL DSMZ 1871 1792 1931 236000 122 SU-DHL-4 DLBCL DSMZ 1097 1046 1053 697000 662 DOHH-2 Follicular DSMZ 888 1172 840 488000 581 MOLT-4 ALL NCI 1494 1280 1310 3606 3 Granta-519* MCL DSMZ 1363 1408 15400 524000 372 Ramos RR XCL Burkitt's ATCC in-vivo selection 679 1093 693 97276 140 (rituxan resistant) Mino MCL ATCC 1438 1409 1484 446000 301 Mino XCL MCL ATCC in-vivo xenograft 201 198 200 63100 316 Ramos Burkitt's ATCC 1232 1117 1151 615000 534 Raji Burkitt's ATCC 1590 1648 1761 237000 135 Daudi Burkitt's ATCC 1513 1780 2039 79000 39 WSU-DLCL-2 DLBCL DSMZ 1214 1149 1203 666000 554 REC-1 MCL DSMZ 870 6149 1013 345554 341 BDCM AML ATCC 219 286 290 18500 64 MOLM-13 AML DSMZ 263 245 240 1514 6 R54-11 ALL ATCC 154 149 155 4054 26 EoL-1 AML Sigma/HPA 197 189 189 604 3 Kasumi-1 AML DSMZ 172 190 188 1710 9 MV-4-11 AML ATCC 263 249 247 2065 8 THP-1 AML ATCC 266 296 324 7355 23 KG-1* AML NCI 985 1787 8190 18100 10 Hel 92.1* AML ATCC 1455 1521 4216 42600 28 HL-60 AML ATCC 867 889 967 4602 5 Note: *All MFR ratios calculated with the Isotype control as reference, except for Granta-519, KG-1 and Hel 92.1 where the secondary detection was used as reference due to the high Isotype control background binding. ..

    Article Title: Antibody drug conjugates (ADC) that bind to CD37 proteins
    Article Snippet: .. CDR Kabat Chothia Contact CDR-L1 L24-L34 L24-L34 L30-L36 CDR-L2 L50-L56 L50-L56 L46-L55 CDR-L3 L89-L97 L89-L97 L89-L96 CDR-H1* H31-H35 H26-H32 H30-H35 CDR-H1** H31-H35 H26-H32 H30-H35 CDR-H2 H50-H65 H52-H56 H47-H58 CDR-H3 H95-H102 H95-H102 H93-H101 *Kabat Numbering **Chothia Numbering TABLE VI Table of Geometric Mean values and Mean Florescence ratio (MFR) values in FACS assay. secondary HvCD37- Cell line Cancer type Source unstained detection Isotype 6b15.1.1 MFR JVM-3 CLL DSMZ 1871 1792 1931 236000 122 SU-DHL-4 DLBCL DSMZ 1097 1046 1053 697000 662 DOHH-2 Follicular DSMZ 888 1172 840 488000 581 MOLT-4 ALL NCl 1494 1280 1310 3606 3 Granta-519* MCL DSMZ 1363 1408 15400 524000 372 Ramos RR XCL Burkitt's ATCC in-vivo selection 679 1093 693 97276 140 (rituxan resistant) Mino MCL ATCC 1438 1409 1484 446000 301 Mino XCL MCL ATCC in-vivo xenograft 201 198 200 63100 316 Ramos Burkitt's ATCC 1232 1117 1151 615000 534 Raji Burkitt's ATCC 1590 1648 1761 237000 135 Daudi Burkitt's ATCC 1513 1780 2039 79000 39 WSU-DLCL-2 DLBCL DSMZ 1214 1149 1203 666000 554 REC-1 MCL DSMZ 870 6149 1013 345554 341 BDCM AML ATCC 219 286 290 18500 64 MOLM-13 AML DSMZ 263 245 240 1514 6 RS4-11 ALL ATCC 154 149 155 4054 26 EoL-1 AML Sigma/HPA 197 189 189 604 3 Kasumi-1 AML DSMZ 172 190 188 1710 9 MV-4-11 AML ATCC 263 249 247 2065 8 THP-1 AML ATCC 266 296 324 7355 23 KG-1* AML NCl 985 1787 8190 18100 10 Hel 92.1* AML ATCC 1455 1521 4216 42600 28 HL-60 AML ATCC 867 889 967 4602 5 Note: *All MFR ratios calculated with the Isotype control as reference, except for Granta-519, KG-1 and Hel 92.1 where the secondary detection was used as reference due to the high Isotype control background binding. ..

    Article Title: Antibody drug conjugates (ADC) that bind to CD37 proteins
    Article Snippet: .. CDR Kabat Chothia Contact CDR-L1 L24-L34 L24-L34 L30-L36 CDR-L2 L50-L56 L50-L56 L46-L55 CDR-L3 L89-L97 L89-L97 L89-L96 CDR-H1* H31-H35 H26-H32 H30-H35 CDR-H1** H31-H35 H26-H32 H30-H35 CDR-H2 H50-H65 H52-H56 H47-H58 CDR-H3 H95-H102 H95-H102 H93-H101 *Kabat Numbering **Chothia Numbering TABLE VI Table of Geometric Mean values and Mean Florescence ratio (MFR) values in FACS assay. secondary HvCD37- Cell line Cancer type Source unstained detection Isotype 6b15.1.1 MFR JVM-3 CLL DSMZ 1871 1792 1931 236000 122 SU-DHL-4 DLBCL DSMZ 1097 1046 1053 697000 662 DOHH-2 Follicular DSMZ 888 1172 840 488000 581 MOLT-4 ALL NCI 1494 1280 1310 3606 3 Granta-519* MCL DSMZ 1363 1408 15400 524000 372 Ramos RR XCL Burkitt's ATCC in-vivo selection (rituxan resistant) 679 1093 693 97276 140 Mino MCL ATCC 1438 1409 1484 446000 301 Mino XCL MCL ATCC in-vivo xenograft 201 198 200 63100 316 Ramos Burkitt's ATCC 1232 1117 1151 615000 534 Raji Burkitt's ATCC 1590 1648 1761 237000 135 Daudi Burkitt's ATCC 1513 1780 2039 79000 39 WSU-DLCL-2 DLBCL DSMZ 1214 1149 1203 666000 554 REC-1 MCL DSMZ 870 6149 1013 345554 341 BDCM AML ATCC 219 286 290 18500 64 MOLM-13 AML DSMZ 263 245 240 1514 6 RS4-11 ALL ATCC 154 149 155 4054 26 EoL-1 AML Sigma/HPA 197 189 189 604 3 Kasumi-1 AML DSMZ 172 190 188 1710 9 MV-4-11 AML ATCC 263 249 247 2065 8 THP-1 AML ATCC 266 296 324 7355 23 KG-1* AML NCI 985 1787 8190 18100 10 Hel 92.1* AML ATCC 1455 1521 4216 42600 28 HL-60 AML ATCC 867 889 967 4602 5 Note: *All MFR ratios calculated with the Isotype control as reference, except for Granta-519, KG-1 and Hel 92.1 where the secondary detection was used as reference due to the high Isotype control background binding. ..

    Binding Assay:

    Article Title: Antibody drug conjugates (ADC) that bind to CD37 proteins
    Article Snippet: .. CDR Kabat Chothia Contact CDR-L1 L24-L34 L24-L34 L30-L36 CDR-L2 L50-L56 L50-L56 L46-L55 CDR-L3 L89-L97 L89-L97 L89-L96 CDR-H1* H31-H35 H26-H32 H30-H35 CDR-H1** H31-H35 H26-H32 H30-H35 CDR-H2 H50-H65 H52-H56 H47-H58 CDR-H3 H95-H102 H95-H102 H93-H101 *Kabat Numbering **Chothia Numbering TABLE VI Table of Geometric Mean values and Mean Florescence ratio (MFR) values in FACS assay. secondary HvCD37- Cell line Cancer type Source unstained detection Isotype 6b15.1.1 MFR JVM-3 CLL DSMZ 1871 1792 1931 236000 122 SU-DHL-4 DLBCL DSMZ 1097 1046 1053 697000 662 DOHH-2 Follicular DSMZ 888 1172 840 488000 581 MOLT-4 ALL NCI 1494 1280 1310 3606 3 Granta-519* MCL DSMZ 1363 1408 15400 524000 372 Ramos RR XCL Burkitt's ATCC in-vivo selection 679 1093 693 97276 140 (rituxan resistant) Mino MCL ATCC 1438 1409 1484 446000 301 Mino XCL MCL ATCC in-vivo xenograft 201 198 200 63100 316 Ramos Burkitt's ATCC 1232 1117 1151 615000 534 Raji Burkitt's ATCC 1590 1648 1761 237000 135 Daudi Burkitt's ATCC 1513 1780 2039 79000 39 WSU-DLCL-2 DLBCL DSMZ 1214 1149 1203 666000 554 REC-1 MCL DSMZ 870 6149 1013 345554 341 BDCM AML ATCC 219 286 290 18500 64 MOLM-13 AML DSMZ 263 245 240 1514 6 R54-11 ALL ATCC 154 149 155 4054 26 EoL-1 AML Sigma/HPA 197 189 189 604 3 Kasumi-1 AML DSMZ 172 190 188 1710 9 MV-4-11 AML ATCC 263 249 247 2065 8 THP-1 AML ATCC 266 296 324 7355 23 KG-1* AML NCI 985 1787 8190 18100 10 Hel 92.1* AML ATCC 1455 1521 4216 42600 28 HL-60 AML ATCC 867 889 967 4602 5 Note: *All MFR ratios calculated with the Isotype control as reference, except for Granta-519, KG-1 and Hel 92.1 where the secondary detection was used as reference due to the high Isotype control background binding. ..

    Article Title: Antibody drug conjugates (ADC) that bind to CD37 proteins
    Article Snippet: .. CDR Kabat Chothia Contact CDR-L1 L24-L34 L24-L34 L30-L36 CDR-L2 L50-L56 L50-L56 L46-L55 CDR-L3 L89-L97 L89-L97 L89-L96 CDR-H1* H31-H35 H26-H32 H30-H35 CDR-H1** H31-H35 H26-H32 H30-H35 CDR-H2 H50-H65 H52-H56 H47-H58 CDR-H3 H95-H102 H95-H102 H93-H101 *Kabat Numbering **Chothia Numbering TABLE VI Table of Geometric Mean values and Mean Florescence ratio (MFR) values in FACS assay. secondary HvCD37- Cell line Cancer type Source unstained detection Isotype 6b15.1.1 MFR JVM-3 CLL DSMZ 1871 1792 1931 236000 122 SU-DHL-4 DLBCL DSMZ 1097 1046 1053 697000 662 DOHH-2 Follicular DSMZ 888 1172 840 488000 581 MOLT-4 ALL NCl 1494 1280 1310 3606 3 Granta-519* MCL DSMZ 1363 1408 15400 524000 372 Ramos RR XCL Burkitt's ATCC in-vivo selection 679 1093 693 97276 140 (rituxan resistant) Mino MCL ATCC 1438 1409 1484 446000 301 Mino XCL MCL ATCC in-vivo xenograft 201 198 200 63100 316 Ramos Burkitt's ATCC 1232 1117 1151 615000 534 Raji Burkitt's ATCC 1590 1648 1761 237000 135 Daudi Burkitt's ATCC 1513 1780 2039 79000 39 WSU-DLCL-2 DLBCL DSMZ 1214 1149 1203 666000 554 REC-1 MCL DSMZ 870 6149 1013 345554 341 BDCM AML ATCC 219 286 290 18500 64 MOLM-13 AML DSMZ 263 245 240 1514 6 RS4-11 ALL ATCC 154 149 155 4054 26 EoL-1 AML Sigma/HPA 197 189 189 604 3 Kasumi-1 AML DSMZ 172 190 188 1710 9 MV-4-11 AML ATCC 263 249 247 2065 8 THP-1 AML ATCC 266 296 324 7355 23 KG-1* AML NCl 985 1787 8190 18100 10 Hel 92.1* AML ATCC 1455 1521 4216 42600 28 HL-60 AML ATCC 867 889 967 4602 5 Note: *All MFR ratios calculated with the Isotype control as reference, except for Granta-519, KG-1 and Hel 92.1 where the secondary detection was used as reference due to the high Isotype control background binding. ..

    Article Title: Antibody drug conjugates (ADC) that bind to CD37 proteins
    Article Snippet: .. CDR Kabat Chothia Contact CDR-L1 L24-L34 L24-L34 L30-L36 CDR-L2 L50-L56 L50-L56 L46-L55 CDR-L3 L89-L97 L89-L97 L89-L96 CDR-H1* H31-H35 H26-H32 H30-H35 CDR-H1** H31-H35 H26-H32 H30-H35 CDR-H2 H50-H65 H52-H56 H47-H58 CDR-H3 H95-H102 H95-H102 H93-H101 *Kabat Numbering **Chothia Numbering TABLE VI Table of Geometric Mean values and Mean Florescence ratio (MFR) values in FACS assay. secondary HvCD37- Cell line Cancer type Source unstained detection Isotype 6b15.1.1 MFR JVM-3 CLL DSMZ 1871 1792 1931 236000 122 SU-DHL-4 DLBCL DSMZ 1097 1046 1053 697000 662 DOHH-2 Follicular DSMZ 888 1172 840 488000 581 MOLT-4 ALL NCI 1494 1280 1310 3606 3 Granta-519* MCL DSMZ 1363 1408 15400 524000 372 Ramos RR XCL Burkitt's ATCC in-vivo selection (rituxan resistant) 679 1093 693 97276 140 Mino MCL ATCC 1438 1409 1484 446000 301 Mino XCL MCL ATCC in-vivo xenograft 201 198 200 63100 316 Ramos Burkitt's ATCC 1232 1117 1151 615000 534 Raji Burkitt's ATCC 1590 1648 1761 237000 135 Daudi Burkitt's ATCC 1513 1780 2039 79000 39 WSU-DLCL-2 DLBCL DSMZ 1214 1149 1203 666000 554 REC-1 MCL DSMZ 870 6149 1013 345554 341 BDCM AML ATCC 219 286 290 18500 64 MOLM-13 AML DSMZ 263 245 240 1514 6 RS4-11 ALL ATCC 154 149 155 4054 26 EoL-1 AML Sigma/HPA 197 189 189 604 3 Kasumi-1 AML DSMZ 172 190 188 1710 9 MV-4-11 AML ATCC 263 249 247 2065 8 THP-1 AML ATCC 266 296 324 7355 23 KG-1* AML NCI 985 1787 8190 18100 10 Hel 92.1* AML ATCC 1455 1521 4216 42600 28 HL-60 AML ATCC 867 889 967 4602 5 Note: *All MFR ratios calculated with the Isotype control as reference, except for Granta-519, KG-1 and Hel 92.1 where the secondary detection was used as reference due to the high Isotype control background binding. ..



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